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ALEXA FLUOR 750 Rabbit anti-Human DOK1(Tyr362) Polyclonal Antibody, ALEXA FLUOR 750 Conjugated [IgG]
Výrobce: Bioss Katalogové č.: bs-5289R-A750 Aplikace: Průtoková cytometrie, Western Blot Reaktivita: Ostatní Původ: Rabbit Klonalita: Polyclonal Konjugát: AlexaFluor750 Laser: 750 nm (infračervený) Podtřída: IgG Status: RUO Dodatečné informace: Produkt na webu výrobce Popis:DOK1 phospho Y362; DOK1 phospho Tyr362; p-DOK1 phospho Y362; docking protein 1 downstream of tyrosine kinase 1; Docking protein 1 p62dok Downstream of tyrosine kinase 1 pp62.; docking protein 1 62kD downstream of tyrosine kinase 1; Docking protein 1 62kD; Docking protein 1 62kD; Docking protein 1; DOK 1; DOK1; DOK-1; DOK1_HUMAN; Downstream of tyrosine kinase 1; p62dok; P62DOK; pp62; pp62.
Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.