CACNB4/L-type Ca++ CP beta 4 Antibody

CAB4; CACB4_HUMAN; Cacnb4; CACNLB4; Calcium channel voltage dependent beta 4 subunit; Calcium channel voltage dependent subunit beta 4; Calcium channel voltage-dependent subunit beta 4; Dihydropyridine sensitive L type calcium channel beta 4 subunit; EA5; EIG9; EJM; EJM4; Voltage-dependent L-type calcium channel subunit beta-4.

Voltagedependent calcium channels are essential for the release of neurotransmitters. Ltype (long lasting current) voltagedependent calcium channels are composed of four subunits: an Alpha1 subunit, a Beta subunit, a Beta subunit and an Alpha2 Gamma subunit. The Beta subunit is encoded by four genes, designated Beta1Beta 4, all of which contribute to the diversity of calcium currents and are involved in membrane trafficking of the Beta subunit. Ltype Ca++ CP Beta 4, also known as CACNB4 (Calcium channel voltagedependent subunit beta 4), CACNLB4 or CAB4, is a 484 amino acid protein that contains one SH3 domain and is expressed in ovary, brain and smooth muscle. Functioning as one of the four components of the Beta subunit, Ltype Ca++ CP Beta 4 increases the peak calcium current in voltagedependent calcium channels, thereby shifting the voltage dependencies of activation and inactivation and controlling G protein inhibition and Beta membrane targeting. Two isoforms of Ltype Ca++ CP Beta4 exist due to alternative splicing events.