Caspase 12 Polyclonal Antibody

Caspase-12; CASP-12; Casp12

Caspases are cysteine proteases that cleave Cterminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated nonfunctional protein. The readthrough codon occurs primarily in individuals of African descent and carriers have endotoxin hyporesponsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011].