ALEXA FLUOR 750 Rabbit anti-Human, Mouse, Rat CXCR4 Polyclonal Antibody, ALEXA FLUOR 750 Conjugated [IgG]

Výrobce: Bioss Katalogové č.: bs-1011R-A750 Aplikace: Imunofluorescence, Průtoková cytometrie Reaktivita: Human, Mouse, Rat Původ: Rabbit Klonalita: Polyclonal Konjugát: AlexaFluor750 Laser: 750 nm (infračervený) Podtřída: IgG Status: RUO Dodatečné informace: Produkt na webu výrobce Popis:

C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; LESTR; Lipopolysaccharide-associated protein 3; LAP-3; LPS-associated protein 3; NPYRL; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD184; CXCR4

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

100ul
14 160 Kč
bez DPH
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