HDAC3/HD3 Polyclonal Antibody

HD3; RPD3; RPD3-2; Histone deacetylase 3; SMAP45; HDAC3

Responsible for the deacetylation of lysine residues on the Nterminal part of the core histones (H2A, H2B, H3 and H4), and some other nonhistone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zincfinger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.