ALEXA FLUOR 750 Mouse anti-Human, Mouse, Rat PCNA (3G1) Monoclonal Antibody, ALEXA FLUOR 750 Conjugated [IgG]

Výrobce: Bioss Katalogové č.: bsm-33035M-A750 Aplikace: Imunofluorescence Reaktivita: Human, Mouse, Rat Původ: Mouse Klonalita: Monoclonal Konjugát: AlexaFluor750 Laser: 750 nm (infračervený) Podtřída: IgG Status: RUO Dodatečné informace: Produkt na webu výrobce Popis:

Proliferating cell nuclear antigen; PCNA; Cyclin

Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.

100ul
5 810 Kč
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