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PI3 kinase p85 alpha subunit Antibody
Výrobce: Bioss Katalogové č.: bs-0128R Aplikace: Western Blot, Imunofluorescence, Imunohistochemie, Průtoková cytometrie, ELISA, ELISPOT Reaktivita: Human, Mouse, Rat, Rabbit Původ: Rabbit Klonalita: Polyclonal Podtřída: IgG Status: RUO Dodatečné informace: Produkt na webu výrobce Popis:p85; AGM7; GRB1; IMD36; p85-ALPHA; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha; PIK3R1
Binds to activated (phosphorylated) proteinTyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p11 catalytic unit to the plasma membrane. Necessary for the insulinstimulated increase in glucose uptake and glycogen synthesis in insulinsensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.