RAR alpha Polyclonal Antibody, Cy3 Conjugated

RAR; Nr1b1; RARalpha1; Retinoic acid receptor alpha; RAR-alpha; Nuclear receptor subfamily 1 group B member 1; Rara

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, alltrans or 9cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'AGGTCA3' sites known as DR1DR5. In the absence of ligand, the RXRRAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Regulates expression of target genes in a liganddependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acidinduced granulopoiesis. RARA plays an essential role in the regulation of retinoic acidinduced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.