SNIP1 Polyclonal Antibody, Cy3 Conjugated

FHA domain-containing protein SNIP1; FLJ12553; Smad nuclear interacting protein Smad nuclear interacting; Smad nuclear interacting protein; Smad nuclear-interacting protein 1; SNIP1 Smad nuclear interacting protein; SNIP1; SNIP1_HUMAN; Splicing factor arginine/serine rich 4 Pre mRNA splicing factor SRP75.

Members of the transforming growth factorbeta (TGFBeta) superfamily play critical roles in controlling cell growth and differentiation. Effects of TGFBeta family ligands are mediated by Smad proteins. The Smad nuclear interacting protein (SNIP1) contains a forkheadassociated (FHA) domain and acts as a nuclear inhibitor of CBP/p300. SNIP1 potently inhibits the activity of NFkappa B, which binds the C/H1 domain of CBP/p300, by competing for the binding site. SNIP1 is also thought to induce expression of Cyclin D1 to promote cellular proliferation. SNIP1 is ubiquitously expressed with high expression in heart and skeletal muscle.