Unconjugated Rabbit anti-Human Phospho-SHIP(Y1020) Monoclonal Antibody [IgG]

Inositol polyphosphate 5 phosphatase of 145kDa antibody, 4 antibody, 5-trisphosphate 5-phosphatase 1 antibody, hp51CN antibody, Inositol polyphosphate 5 phosphatase 145kDa antibody, Inositol polyphosphate 5 phosphatase antibody, Inositol polyphosphate-5-phosphatase of 145 kDa antibody, INPP5D antibody, MGC104855 antibody, MGC142140 antibody, MGC142142 antibody, p150Ship antibody, Phosphatidylinositol 3,4,5 trisphosphate 5 phosphatase 1 antibody, Phosphatidylinositol-3 antibody, SH2 containing inositol phosphatase isoform b antibody, SH2 domain containing inositol 5' phosphatase 1 antibody, SH2 domain containing inositol phosphatase 1 antibody, SH2 domain-containing inositol phosphatase 1 antibody, SH2 domain-containing inositol-5'-phosphatase 1 antibody, SHIP-1 antibody, SHIP1 antibody, SHIP1_HUMAN antibody, Signaling inositol polyphosphate 5 phosphatase SIP 145 antibody, SIP-145 antibody, SIP145 antibody

SHIP1 is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and contains an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation in response to multiple cytokine and B and T cell receptor activation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall the protein functions as a negative regulator of myeliod cell proliferation and survival.